FiltersDone

Question type

Essay

Multiple Choice

Short Answer

True False

Matching

Exam 20: Genomics and Proteomics

Show Answer

Share

---

All types

Filters

Study Flashcards

Question 21

Multiple Choice

Review LaterAdd Note

Review Later

Which of the following statements about eukaryotic genomes is TRUE?

A) A substantial part of the genomes of most multicellular organisms consists of protein coding sequences.
B) People differ not only at millions of individual SNPs but also in the number of copies of many larger segments of the genome.
C) In humans, the number of proteins is approximately equal to the total number of genes.
D) There is a directly proportional relationship between the size of a eukaryotic organism and the number of genes it has.
E) The number of genes among multicellular eukaryotes is related to phenotypic complexity.

F) All of the above
G) C) and D)

Correct Answer

verified

Show Answer

Question 22

Multiple Choice

Review LaterAdd Note

Review Later

A _____ is a group of evolutionarily related genes that arose through repeated evolution of an ancestral gene.

A) microarray
B) multigene family
C) proteome
D) haplotype
E) contig

F) B) and C)
G) A) and B)

Correct Answer

verified

Show Answer

Question 23

Multiple Choice

Review LaterAdd Note

The expression of miRNAs was compared in normal cells and cancer cells using a microarray. miRNAs from cancer cells were labeled with green fluorescent tags, and miRNAs from normal cells were labeled with red fluorescent tags. miRNA #1 was overexpressed in cancer cells, miRNA #2 was not expressed in either cell type, miRNA #3 was underexpressed in cancer cells, and miRNA #4 was equally expressed in both cell types. Which of the following microarrays illustrate these findings?

Use the following to answer questions A researcher is interested in studying Drosophila genes that are turned on in response to UV light exposure. She uses a microarray to carry out her experiment and is particularly interested in eight genes shown in the microarray below. $\bullet$ Vertical stripes mean hybridization to UV light-exposed cell cDNA only. $\bullet$ Horizontal stripes mean hybridization to nonexposed cell cDNA only (control) . $\bullet$ Completely filled in means hybridization to both cDNA types. $\bullet$ Blank means hybridization to neither cell's cDNA. -Which genes appear to be downregulated in the UV light-exposed group?

Linkage disequilibrium is the nonrandom association among SNPs within a haplotype. Over time, would you expect linkage disequilibrium among markers to be maintained, to increase, or to decrease?

How are SNPs used to search for genes causing disease?

Which of the following is TRUE of noncoding DNA?

Compare the fields of structural, functional, and comparative genomics. What is the purpose of each?

Which of the following is involved in the RNA sequencing process?

A typical prokaryotic genome has:

The transcriptome of a genome contains more components than the proteome. Explain why this is true.

Which of the following information CANNOT be learned from RNA sequencing?

Describe how a reporter sequence could be used to reveal information about gene expression.

A BLAST search is done to:

You obtain six BACs (of known order, shown below) and six sequence-tagged sites (STSs, of unknown order) derived from an unfinished portion of the genome sequence of Monodelphis domestica, the gray short-tailed opposum. Using PCR, you test each BAC for the presence (+) or absence (-) of each of the STSs. You obtain the following results: Construct a physical map that shows the order of the STSs and their approximate locations within each BAC.

In the following list of cloned fragments, which are the fragments needed to make the longest possible contig with the least amount of overlap? $\begin{array}{c}\begin{array}{lll}Cloned ~fragment\\\hline A\\B\\C\\D\\E\\F\\\end{array}&\begin{array}{lll}Markers~~ present\\\hline M4~~ M5\\\hline M1~~ M2 ~~M3\\\hline M6~~ M7~~ M8\\\hline M3~~ M4~~ M5~~ M6\\\hline M3~~ M4~~ M5\\\hline M8~~ M9~~ M10\\\hline\end{array}\end{array}$

In general, what kind of information can be obtained from homologous genes?

Use the following to answer questions $\begin{array} { | l r r | } \hline \text { Species } & \begin{array} { c } \text { Genome Size (millions of } \\\text { base pairs) }\end{array} & \text { Number of Predicted Genes } \\\hline \text { Saccharomyces cerevisiae (yeast) } & 12 & 6,144 \\\hline \text { Drosophila melanogaster (fruit fly) } & 170 & 13,525 \\\hline \text { Mus musculus (mouse) } & 2,627 & 26,762 \\\hline \text { Pan troglodytes (chimpanzee) } & 2,733 & 22,524 \\\hline \text { Homo sapiens (human) } & 3,223 & \sim 20,000 \\\hline\end{array}$ -Based on the table above, which species has the LOWEST gene density?

Given the 2D-PAGE gel below, which one of the following conclusions is true? [Figure after G. Gibson and S. Muse. 2004. A Primer of Genome Science, 2e. Sinauer Associates, Inc. p. 274, Fig. 5.4.]

Which of the following statements is TRUE of genetic maps?