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Nitrate can be reduced to ammonia by virtually all organisms.

A) True
B) False

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The common degradation product of lysine, tryptophan, phenylalanine and tyrosine is ________.

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All amino acids can be synthesized from intermediates of the:


A) glycolytic pathway alone.
B) glycolytic pathway and the pentose phosphate pathway.
C) citric acid cycle alone.
D) the glycolytic pathway and citric acid cycle.
E) the glycolytic pathway, the pentose phosphate pathway and citric acid cycle.

F) A) and B)
G) A) and E)

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E

Tyrosine is the precursor of serotonin which has a number of roles in the nervous system.

A) True
B) False

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The catecholamine neurotransmitters are derived from ________.

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Transamination reactions can be used to degrade or synthesize amino acids because they have an ________ that has a value close to one.

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equilibrium constant

________ high energy phosphates from ATP are consumed in each turn of the urea cycle.

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Apart from in the synthesis of methionine, S-adenosylmethionine is the only biological ________ group donor.

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N2 gas can be converted to NH3 by:


A) most organisms.
B) mammals.
C) all plants.
D) all bacteria.
E) legumes.

F) A) and E)
G) A) and B)

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The oxidation of branched chain amino acids shares a similar chemical strategy with β-oxidation of fatty acids.

A) True
B) False

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Tetrahydrofolate is a coenzyme involved in the mobilization and utilization of single carbon functional units in the:


A) metabolism of serine, glycine, methionine, and histidine.
B) biosynthesis of purine nucleotides.
C) biosynthesis of thymine.
D) biosynthesis of formylmethionyl-tRNA.
E) all of the above.

F) C) and D)
G) A) and E)

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Pyridoxal phosphate is a versatile coenzyme as it is capable of forming a stable ________ base between an amino acid substrate and the coenzyme.

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Folate deficiency results in increased risk of cardiovascular disease associated with abnormally high levels of serum ________ due to decreased levels of tetrahydrofolate cofactors required for the methionine synthase reaction.

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Which of the following enzymes is NOT involved in the conversion of NH3 to an organic nitrogen-containing compound?


A) Glutamate dehydrogenase
B) Carbamoyl phosphate dehydrogenase
C) Glutamate-oxaloacetate transaminase
D) Glutamine synthetase
E) Asparagine synthetase

F) B) and C)
G) B) and D)

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Nitrogen fixation requires the hydrolysis of 8 ATPs to produce 2 NH3 molecules from 1 N2.

A) True
B) False

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Which of the following amino acids is both glucogenic and ketogenic?


A) Lysine
B) Leucine
C) Tryptophan
D) Cysteine
E) Arginine

F) None of the above
G) A) and E)

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C

Which of the following amino acids cannot be used to provide an intermediate of the citric acid cycle?


A) Histidine
B) Proline
C) Phenylalanine
D) Lysine
E) Tyrosine

F) B) and C)
G) A) and D)

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The H2S produced by metabolism of cysteine is a waste product with no physiological or biochemical function.

A) True
B) False

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In the degradation of amino acids in muscle NH4+ is carried to the liver for conversion into urea by:


A) glutamine.
B) asparagine.
C) alanine.
D) either alanine or glutamine.
E) any amino acid.

F) A) and B)
G) All of the above

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The Krebs-Henseleit urea cycle takes place in liver cells entirely within the mitochondrion.

A) True
B) False

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